When I first started to learn about nutrition, I found a lot of conflicting information about protein. The USFDA recommendations were very low. Advise to body builders was extremely high. There seemed to be differing views about optimal timing, the minimum effective dose, maximum effective dose, etc. Yesterday I listed to podcast #224 ‒ Dietary protein: amount needed, ideal timing, quality, and more | Don Layman, Ph.D. – Peter Attia. The discussion between Attia and Don Layman crystalized everything I had read, and a quick email with Don confirmed my understand.


  • Older adults should consume 2 grams / 1 kg of LEAN body weight. People generally don’t know their lean body weight, so the most common recommendations assume 20% body fat resulting in a recommendation of 1.6 grams / 1 kg of body weight, which is .73 grams / 1 lb body weight.
  • Minimum effective dose in adults is around 25 grams / meal. Less than that you are you feeding other systems, but not triggering muscle synthesis which you really want!!
  • Maximum effective dose for muscle synthesis is around 50 grams. Above that, it’s turned into fuel for organs or saved as fat.
  • In the first 3 months of new training, get protein within 2 hours. Otherwise timing doesn’t matter
  • Make sure your first, and last meals have adequate protein. Ideally approach the maximum dose in your first meal.


Protein is needed by the body. The body needs around 300 grams of “new” protein / day. Most of this comes by way of recycling within the body. As we age, the recycling becomes less effective requiring us to consume more protein.

There are a wide variety of proteins which our body produces from over 20 different amino acids. There are nine essential amino acids that our body can’t produce. We need to consume them. The protein we eat gets broken down and then used.

It is useful to think about dietary protein as a vitamin containing essential amino acids. The % of macro-nutrients in our diet from protein isn’t so important. What’s critical is that we are consuming enough (e.g. it’s an absolute number).

For adults (>25) it’s critical to consume enough essential amino acids, which we typically get through the consumption of protein, to drive muscle synthesis. Protein (for this purpose) is not so important in younger folks whose muscle synthetic is driven by hormones

Useful References

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